ANCAs Are Also Antimonocyte Cytoplasmic Autoantibodies
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چکیده
منابع مشابه
ANCAs are also antimonocyte cytoplasmic autoantibodies.
Names can be misleading. The term ANCA is a misnomer, because ANCAs recognize antigens that are in not only the primary granules of neutrophils but also, the peroxidase-positive lysosomes of monocytes, including both proteinase 3 (PR3) and myeloperoxidase (MPO). The first published article on ANCA was in 1982 by Davies et al. (1), who reported eight patients with segmental necrotizing GN who al...
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Neutrophils are pivotal to host defence during infectious diseases. However, activated neutrophils may also cause undesired tissue damage. Ample examples include small-vessel inflammatory diseases (vasculitis) that are associated with anti-neutrophil cytoplasmic autoantibodies (ANCA) residing in the patients' plasma. In addition to being an important diagnostic tool, convincing evidence shows t...
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ژورنال
عنوان ژورنال: Clinical Journal of the American Society of Nephrology
سال: 2014
ISSN: 1555-9041,1555-905X
DOI: 10.2215/cjn.11501114